Ribosomal protein L10



Ribosomal protein L10 (RPL10) is one of the 34 proteins which belong to the large 50S subunit of the prokaryotic ribosome or to the ca. 49 proteins in the large 60S subunit of the eukaryotic ribosome. It is found mostly in eubacteria. The L10 forms a complex with a dimer of L7/L12. This complex is called L8. The acidic ribosomal protein P0 is the equivalent of the 50S L10 and the 60S L10E. The images at the left and at the right correspond to one representative RPL10, i.e. the crystal structure of Ribosomal protein L10 from Thermus thermophilus (2xg0, chain J).

3D Structures of Ribosomal protein L10
Update June 2011

RPL10
3jsy – RPL10 N-terminal – Methanocaldocoddus jannaschii

2pa2 – RPL10 core domain – human

1zav, 1zaw, 1zax – RPL10+RPL7 N-terminal – Thermotoga maritima

3a1y - RPL10 N-terminal+RPL12 – Pyrococcus horikoshii

L10 in 50S subunit+RNA
2xg0, 2xg2, 3kir, 3kit, 3kiw, 3kiy – TtRPL10 in 50S subunit+RNA fragments - Thermus thermophilus

2x9s, 2x9u, 2wrj, 2wrl, 2wro, 2wrr, 2wh2, 2wh4, 2j01, 2j03, 3mrz, 3ms1, 3i8i, 3d5b, 3d5d, 2xqe, 2y0v, 2y0x, 2y0z,  2y11, 2y13, 2y15, 2y17, 2y19, 3pyo, 3pyr,  3pyt, 3pyv -  TtRPL10 in 50S subunit+5S RRNA+23S RRNA

1kqs, 1qvg - HmRPL10P in 50S subunit+5S RRNA+23S RRNA+CCA - Haloarcula marismortui

1jj2, 1ffk, 3cc2, 2qa4, 1s72 - HmRPL10P in 50S subunit+5S RRNA+23S RRNA

3cc7, 3cce, 3ccj, 3ccl, 3ccm, 3ccq, 3ccr, 3ccs, 3ccu, 3ccv - HmRPL10P in 50S subunit+5S RRNA+23S RRNA (mutant)

1yj9 - HmRPL10P in 50S subunit (L22 mutant)+5S RRNA+23S RRNA

1vq4, 1vq5, 1vq7, 1vql, 1vqm, 1vqp - HmRPL10P in 50S subunit+5S RRNA+23S RRNA+transition state analog

1vq6, 1vqk, 1vqn - HmRPL10P in 50S subunit+5S RRNA+23S RRNA+ c-hpmn+CCA-Phe-caproic acid-biotin

1q86 - HmRPL10P in 50S subunit+5S RRNA+23S RRNA+CCA-Phe-caproic acid-biotin

1vqo - HmRPL10P in 50S subunit+5S RRNA+23S RRNA+ CCPMN

1qvf - HmRPL10P in 50S subunit+5S RRNA+23S RRNA + deacylated tRNA minihelix

L10 in 50S subunit + antibiotics
1k73, 1kc8, 1k8a, 1k9m, 1kd1, 1m1k, 3i55, 3i56, 3g4s, 3g6e, 3g71, 2qex, 3cpw, 3cc4, 3cd6, 2otj, 2otl, 1yit, 1q7y, 1q81, 1q82, 1n8r, 1nji, 3cxc - HmRPL10P in 50S subunit+5S RRNA+23S RRNA+antibiotic - Halobacterium marismortui

1yhq, 1yi2, 1yij, 1yjn, 1yjw - HmRPL10P in 50S subunit+5S RRNA+23S RRNA (mutant)+antibiotic

1m90, 3cma, 3cme, 1vq8, 1vq9 - HmRPL10P in 50S subunit+5S RRNA+23S RRNA+ sparsomycin+CCA-Phe-caproic acid-biotin

L10 in 60S subunit
3jyw - RPL10 in 60S subunit – Thermomyces lanuginosus – Cryo-EM

1s1i - yRPL10 in 40S ribosomal subunit+18S RRNA+elongation factor 2 – Cryo-EM – yeast

3o58, 3o5h – yRPL10 in 60S ribosomal subunit+25S RRNA+5S RRNA+5.8S RRNA

3izr – RPL10 in 60S subunit – wheat – Cryo EM

L10 in large + small ribosomal subunit
2zkr - RPL10 in 60S ribosomal subunit+30S ribosomal subunit+28S RRNA+5.8S RRNA – Cryo-EM – dog

L10 in 50S subunit + various proteins
1w2b - HmRPL10P in 50S subunit+5S RRNA+23S RRNA+trigger factor N-terminal